THE CAMP EFFECT OF ACTINOBACILLUS-PLEUROPNEUMONIAE IS CAUSED BY APX TOXINS

被引：14

作者：

JANSEN, R

BRIAIRE, J

KAMP, EM

GIELKENS, ALJ

SMITS, MA

机构：

[1] DLO,INST ANIM SCI & HLTH,DEPT MOLEC BIOL,8200 AB LELYSTAD,NETHERLANDS

[2] DLO,DEPT ANIM SCI & HLTH,DEPT BACTERIOL,8200 AB LELYSTAD,NETHERLANDS

来源：

FEMS MICROBIOLOGY LETTERS | 1995年 / 126卷 / 02期

关键词：

ACTINOBACILLUS PLEUROPNEUMONIAE; CAMP; APR TOXINS;

D O I：

10.1111/j.1574-6968.1995.tb07407.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Actinobacillus pleuropneumoniae shows synergistic haemolysis when cocultured with Staphylococcus aureus on blood agar plates. This CAMP effect has been attributed to a discrete CAMP factor, but also to the A. pleuropneumoniae-RTX-toxins I, II, and III. We examined the CAMP effect of recombinant Escherichia coli strains that secreted each of these toxins, and of A. pleuropneumoniae mutant strains that were devoid of one or more these toxins. We found that the E. coli strains were CAMP positive, whereas the A. pleuropneumoniae strain devoid of functional toxin genes was CAMP negative. This demonstrated that the CAMP effect of A. pleuropneumoniae is caused by the toxins and that no CAMP factor per se exists.

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页码：139 / 143

页数：5

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