URINARY CYCLIC-AMP IN HYPER-THYROIDISM

Urinary cyclic AMP was studied in 22 female and in 6 male hyperthyroid normocalcemic patients and in 3 hyperthyroid hypercalcemic men. Cyclic AMP/creatinine ratios were elevated both in female (4.12 ± 0.26 μmoles/gm creatinine) and male (3.92 ± 0.41 μmoles/gm creatinine) hyperthyroid normocalcemic patients as compared with normal female and male controls (2.85 ± 0.20 and 2.54 ± 0.14 μmoles/gm creatinine, respectively). However, there was no difference in the 24-hour urinary cyclic AMP excretion of either hyperthyroid or normal subjects. The hyperthyroid hypercalcemic men excreted less (2.47 ± 0.19 μmoles/24 hr) cyclic AMP/24 hr than the normal male controls. In the thirteen female patients, studied when euthyroid, the cyclic AMP/creatinine ratio was normalised.