6-OXA ISOSTERES OF URACIL AND THYMINE

被引：8

作者：

MASINGALE, RE

BRYANT, SR

SKINNER, CG

NASH, J

KRUSE, PF

机构：

[1] North Texas Slate University, Department of Chemistry, Denton

[2] Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 01期

关键词：

D O I：

10.1021/jm00301a040

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6-Oxadihydrouracil has been demonstrated to inhibit growth in several microbial systems, and its toxicity is competitively reversed by uracil and uridine, whereas 6-oxadihydrothymine is not significantly inhibitory to growth of any of the organisms studied. In contrast, growth of mammalian tissue culture cells is essentially unaffected by the presence of either oxygen isosterie analog. In general, the oxygen isosteres are slightly more toxic than the corresponding nitrogen analogs for Escherichia coli strain; however, the reverse is true for lactic acid bacteria. © 1969, American Chemical Society. All rights reserved.

引用

页码：152 / +

页数：1

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