RELATIONSHIP BETWEEN THE CHEMICAL-STRUCTURE AND ANTI-TUMOR ACTIVITY OF GLUCANS PREPARED FROM GRIFORA-UMBELLATA

被引：58

作者：

MIYAZAKI, T

OIKAWA, N

YADOMAE, T

YAMADA, H

YAMADA, Y

HSU, HY

ITO, H

机构：

[1] TOKYO COLL PHARM,DEPT CHEM,HACHIOJI,TOKYO 19203,JAPAN

[2] BRION RES INST TAIWAN,TAIPEI,TAIWAN

[3] UNIV MIE,SCH MED,DEPT PHARMACOL,TSU 514,JAPAN

来源：

CARBOHYDRATE RESEARCH | 1979年 / 69卷 / MAR期

关键词：

D O I：

10.1016/S0008-6215(00)85761-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucans from Grifora umbellata and their enzyme-treated fractions have been tested for antitumour activity against subcutaneously implanted Sarcoma 180 (solid type). The results indicate that the basic common unit of the glucans is of primary importance for the antitumour activity, which is also influenced by the type of sugar linkage, length of branch, branching frequency, molecular size, and molecular conformation. © 1979.

引用

页码：165 / 170

页数：6

共 13 条

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[5] CARBOXYMETHYLPACHYMARAN, A NEW WATER SOLUBLE POLYSACCHARIDE WITH MARKED ANTITUMOUR ACTIVITY
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[6] ITO H. F., 1973, MIE MED J, V23, P117
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[9] MIYAZAKI T, 1974, CHEM PHARM BULL, V22, P1739
[10] STUDIES ON FUNGAL POLYSACCHARIDES .22. STRUCTURAL EXAMINATION OF ANTITUMOUR, WATER-SOLUBLE GLUCANS FROM GRIFORA-UMBELLATA BY USE OF 4 TYPES OF GLUCANASE
MIYAZAKI, T
OIKAWA, N
YAMADA, H
YADOMAE, T
[J]. CARBOHYDRATE RESEARCH, 1978, 65 (02) : 235 - 243

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