DRUG ENTRAPMENT AND RELEASE FROM MULTILAMELLAR AND REVERSE-PHASE EVAPORATION LIPOSOMES

被引：60

作者：

TAYLOR, KMG

TAYLOR, G

KELLAWAY, IW

STEVENS, J

机构：

[1] FISONS PLC,DIV PHARMACEUT,LOUGHBOROUGH,ENGLAND

[2] UNIV COLL CARDIFF,WELSH SCH PHARM,CARDIFF CF1 1XL,S GLAM,WALES

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 58卷 / 01期

关键词：

Controlled drug release; Drug carrier; Drug delivery system; Liposomal entrapment; Liposome; Sodium cromoglycate;

D O I：

10.1016/0378-5173(90)90286-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The entrapment of sodium cromoglycate was determined in multilamellar liposomes prepared from natural and synthetic phospholipids. Drug entrapment was low, but was increased by inclusion of cholesterol or stearylamine into vesicle bilayers. Reverse-phase evaporation vesicles entrapped greater amounts of drug than multilamellar liposomes of the same composition. The rate of drug efflux from liposomes was determined in vitro and was dependent upon bilayer composition and the method of preparation. © 1990.

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页码：49 / 55

页数：7

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