EFFECT OF UBIQUITIN ON PLATELET FUNCTIONS - POSSIBLE IDENTITY WITH PLATELET ACTIVITY SUPPRESSIVE LYMPHOKINE (PASL)

被引：38

作者：

PANCRE, V ^{[1
]}

PIERCE, RJ ^{[1
]}

FOURNIER, F ^{[1
]}

MEHTALI, M ^{[1
]}

DELANOYE, A ^{[1
]}

CAPRON, A ^{[1
]}

AURIAULT, C ^{[1
]}

机构：

[1] UNIV LILLE 1,LILLE & TRANSGENE SA,F-59655 VILLENEUVE DASCQ,FRANCE

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 11期

关键词：

D O I：

10.1002/eji.1830211113

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In an attempt to clone a suppressive lymphokine of platelet function (PASL), we have obtained a cDNA clone coding for the previously described human ubiquitin-80 amino acid fusion protein. Our clone differs from the described sequence in that it contains the complete amino acid sequence of ubiquitin as well as a short (25 bp) 5' noncoding region. In addition the 3' untranslated region is slightly longer than that previously shown. Like PASL, purified ubiquitin can inhibit the cytotoxic properties of platelets and the production of oxygen metabolites by these cells. Moreover, this molecule is able to act as a proaggregating factor and seems of a great interest in pathologies involving defects in platelet aggregation. Ubiquitin could also have a potential use in the regulation of immunological disorders in which platelets seem to be implicated such as hymenoptera venom hypersensitivity and aspirin-sensitive asthma, since in both situations, ubiquitin is able, as is PASL, to inhibit the cytotoxic function of platelets. Indeed ubiquitin possesses important pharmacological potentialities which have not been previously described. This molecule and PASL share several similarities in their functional and physicochemical properties. PASL could therefore belong to the family of ubiquitins.

引用

页码：2735 / 2741

页数：7

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