ACUTE EXPOSURE TO CADMIUM CAUSES TIME-DEPENDENT LIVER-INJURY IN RATS

被引：26

作者：

THEOCHARIS, S

MARGELI, A

FASITSAS, C

LOIZIDOU, M

DELICONSTANTINOS, G

机构：

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1991年 / 99卷 / 1-2期

关键词：

D O I：

10.1016/0742-8413(91)90087-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Serum enzymes activities of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT), after intraperitoneal injection of CdCl2 showed a maximum increase at 12 hours, contrary to the alkaline phosphatase (ALP) that showed a permanent decrease by that time. 2. Cadmium concentration in liver showed an increase at 6 and 12 hours, a decrease at 18, and a re-establishment to the initial values at 24 hours. 3. Liver microsomal membrane fluidity showed an increase at 6 hours followed by a decrease within 24 hours. Free radical generation was decreasing gradually up to 24 hours. 4. Gradually increasing changes were observed from the histological study.

引用

页码：127 / 130

页数：4

共 15 条

[1] EFFECT OF CADMIUM CHLORIDE ON HEPATIC LIPID-PEROXIDATION IN MICE [J].