HUMAN CHORIONIC-GONADOTROPIN RAISES SERUM IMMUNOREACTIVE INHIBIN LEVELS IN MEN WITH HYPOGONADOTROPIC HYPOGONADISM

被引：13

作者：

BURGER, HG ^{[1
]}

TIU, SC ^{[1
]}

BANGAH, ML ^{[1
]}

DEKRETSER, DM ^{[1
]}

机构：

[1] MONASH UNIV,DEPT ANAT,CLAYTON,VIC 3168,AUSTRALIA

来源：

REPRODUCTION FERTILITY AND DEVELOPMENT | 1990年 / 2卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1071/RD9900137

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inhibin is a gonadal glycoprotein hormone involved in the regulation of FSH. To elucidate the regulation of inhibin production we investigated the acute (daily for 1 week) and chronic (9-10 months of follow-up) changes in immunoreactive inhibin, testosterone, LH and FSH levels in the serum of three hypogonadotrophic hypogonadal patients treated first with hCG alone (for 3-6 months) and then hCG combined with FSH (1-5 months). One patient was unexpectedly resistant to gonadotrophin therapy; in the other two, hCG, with or without FSH, caused а rise in inhibin and testosterone, supporting previous observations that LH, as well as FSH, plays a role in the regulation of inhibin or inhibin-related peptides in men. © CSIRO 1990.

引用

页码：137 / 144

页数：8

共 24 条

[1]

AU CL, 1984, J REPROD FERTIL, V71, P259, DOI 10.1530/jrf.0.0710259

[2]

AU CL, 1986, J REPROD FERTIL, V76, P257, DOI 10.1530/jrf.0.0760257

[3] EFFECTS OF HYPOPHYSECTOMY AND SUBSEQUENT FSH AND TESTOSTERONE TREATMENT ON INHIBIN PRODUCTION BY ADULT-RAT TESTES [J].