PLASMA-LEVELS OF IMIPRAMINE (IMI) AND DESMETHYLIMIPRAMINE (DMI) AND CLINICAL-RESPONSE IN PREPUBERTAL MAJOR DEPRESSIVE DISORDER - PRELIMINARY-REPORT

被引：101

作者：

PUIGANTICH, J ^{[1
]}

PEREL, JM ^{[1
]}

LUPATKIN, W ^{[1
]}

CHAMBERS, WJ ^{[1
]}

SHEA, C ^{[1
]}

TABRIZI, MA ^{[1
]}

STILLER, RL ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,NEW YORK,NY 10032

来源：

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY | 1979年 / 18卷 / 04期

关键词：

D O I：

10.1016/S0002-7138(09)62210-X

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

A study is in progress to examine the relationship between clinical response to imipramine (IMI) of prepubertal major depressive disorder at 5 weeks and plasma levels of IMI and its metabolite desmethylimipramine (DMI). Data are presented on the first 13 children in the study. A strong correlation is emerging in nondelusional subjects between total plasma level and clinical response. A total plasma level of 146 ng/ml separates respondent from nonresponders. These data parallel those previously reported in adult major depressive disorder by several investigators. © 1979, The American Academy of Child Psychiatry. All rights reserved.

引用

页码：616 / 627

页数：12

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