RAPID-DETERMINATION OF CARBAMAZEPINE IN HUMAN PLASMA AND SALIVA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：3

作者：

AVGERINOS, A

MALAMATARIS, S

机构：

[1] Department of Pharmacy, University of Thessaloniki

来源：

ANALYTICAL LETTERS | 1991年 / 24卷 / 05期

关键词：

CARBAMAZEPINE; HPLC; HUMAN PLASMA AND SALIVA;

D O I：

10.1080/00032719108052944

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rapid high-performance liquid chromatographic method for the determination of carbamazepine in both plasma and saliva is described. A deproteinization but no extraction step is involved, simplifying the assay. The chromatographic system consists of a reversed-phase C18-Spherisorb column with acetonitrile/0.1 M sodium acetate (40:60 v/v, pH 6.9) as the mobile phase. The method can accurately measure concentrations down to 0.02-mu-g.ml-1, using 0.5 ml sample and covers the entire concentration range normally encountered during therapy. The total run time is under 6 min and the typical assay time is less than 15 min.

引用

收藏

页码：809 / 815

页数：7

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