ENTER A NEW POSTTRANSLATIONAL MODIFICATION - D-AMINO ACIDS IN GENE-ENCODED PEPTIDES

被引:68
作者
MOR, A
AMICHE, M
NICOLAS, P
机构
[1] A. Mor, M. Amiche and P. Nicolas are at the Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Université Paris 7, 2 place Jussieu
关键词
D O I
10.1016/0968-0004(92)90333-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The post-translational processing of peptides plays a key role in conferring biological activity on those peptides. Recently, ribosomally made peptides that contain D-amino acids at specific positions have been discovered in microorganisms as well as in vertebrates and invertebrates. This points to yet another strategy of circumventing stereochemical limitations imposed by the genetic code and conveying biological activity to otherwise inert molecules.
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页码:481 / 485
页数:5
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