UNIFICATION OF THE FERRITIN FAMILY OF PROTEINS

被引:84
作者
GROSSMAN, MJ [1 ]
HINTON, SM [1 ]
MINAKBERNERO, V [1 ]
SLAUGHTER, C [1 ]
STIEFEL, EI [1 ]
机构
[1] EXXON RES & ENGN CO,ROUTE 22 E,CLINTON TOWNSHIP,ANNANDALE,NJ 08801
关键词
IRON METABOLISM; HEME PROTEIN; IRON STORAGE; AEROBIC ORGANISMS; AIDS;
D O I
10.1073/pnas.89.6.2419
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ferritin is the iron-storage protein of eukaryotic organisms. The nucleotide sequence encoding Azotobacter vinelandii bacterioferritin, a hemoprotein, was determined. The deduced amino acid sequence reveals a high degree of identity with Escherichia coli bacterioferritin and a striking similarity to eukaryotic ferritins. Moreover, derivation of a global alignment shows that virtually all key residues specifying the unique structural motifs of eukaryotic ferritin are conserved or conservatively substituted in the A. vinelandii sequence. The alignment suggests specific methionine residues as heme-binding ligands in bacterioferritins. The overall sequence similarity with conservation of key structural residues implies that all ferritins form a unified family of proteins. The results implicate ferritins as proteins potentially common to all aerobic organisms and as such useful in taxonomic classification, evolutionary analysis, and environmental monitoring.
引用
收藏
页码:2419 / 2423
页数:5
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