SYNTHESIS, CHARACTERIZATION AND COMPARATIVE-STUDY OF AMINOPHOSPHONATE CHELATES OF GADOLINIUM(III) IONS AS MAGNETIC-RESONANCE-IMAGING CONTRAST AGENTS

被引：17

作者：

BLIGH, SWA

HARDING, CT

MCEWEN, AB

SADLER, PJ

KELLY, JD

MARRIOTT, JA

机构：

[1] UNIV LONDON,BIRKBECK COLL,DEPT CHEM,GORDON HOUSE,29 GORDON SQ,LONDON WC1H 0PP,ENGLAND

[2] AMERSHAM INT PLC,AMERSHAM LABS,AMERSHAM HP7 9LL,BUCKS,ENGLAND

来源：

POLYHEDRON | 1994年 / 13卷 / 12期

关键词：

D O I：

10.1016/0277-5387(94)80018-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Gadolinium(III) complexes of aminophosphonates, including a novel ligand LH-4(8), have been investigated as potential contrast agents for NMR imaging. Water H-1 relaxivities at 10 and 200 MHz were determined and luminescence measurements, on Tb(III) complexes, allowed the determination of the number of coordinated H2O molecules. The complexes bound strongly to hydroxyapatite, suggesting possible targetting to bone in vivo. This was confirmed by Gd-153 tracer studies with the most favourable biodistribution in rats being shown by gadolinium(III) ethylenediamine-N,N,N',N'-tetrakis(methylenephosphonate).

引用

页码：1937 / 1943

页数：7

共 28 条

[1]

ATLAN H, 1986, J NUCL MED, V27, P20

[2]

BLIGH SWA, 1969, CLIN NMR SPECTROSCOP, P71

[3] PROTON RELAXATION TIMES IN PARAMAGNETIC SOLUTIONS [J].