THE ROLE OF HEPATITIS-C VIRUS IN HEPATOCELLULAR-CARCINOMA IN JAPAN

被引：21

作者：

KANEKO, S

UNOURA, M

TAKEUCHI, M

TERASAKI, S

OGINO, H

MATSUSHITA, E

KOBAYASHI, K

机构：

[1] First Department Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Ishikawa 920

来源：

INTERVIROLOGY | 1994年 / 37卷 / 02期

关键词：

CHRONIC HEPATITIS; CIRRHOSIS; HEPATITIS B VIRUS; PRIMARY BILIARY CIRRHOSIS;

D O I：

10.1159/000150364

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Increasing numbers of patients with hepatocellular carcinoma (HCC) have been reported in Japan. In this paper, we investigated the role of hepatitis C virus (HCV) in HCC and the reason for the increase, using patients admitted to our university hospital from 1945 to 1992. 99 (73%) of 135 patients with HCC were positive for anti-HCV. Prospective studies demonstrated that 22 of 158 (14%) patients with chronic hepatitis C, and 31 of 70 (44%) cirrhotic patients with anti-HCV developed to HCC during the follow-up period (10.1 +/- 3.3 and 7.3 +/- 3.5 years, respectively). Prolonged survival of cirrhotic patients during past decades would also contribute to the increasing number of HCC cases as well as the number of HCV infections in Japan.

引用

页码：108 / 113

页数：6

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