DIRECT DETERMINATION OF THE ENANTIOMERS OF HALOFANTRINE AND ITS PHARMACOLOGICALLY ACTIVE METABOLITE N-DESBUTYLHALOFANTRINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：11

作者：

TEREFE, H ^{[1
]}

BLASCHKE, G ^{[1
]}

机构：

[1] UNIV MUNSTER,INST PHARMACEUT CHEM,HITTORFSTR 58-62,W-4400 MUNSTER,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 615卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80352-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The enantiomers of halofantrine and its main metabolite, N-desbutylhalofantrine, were separated on two different polysaccharide-based chiral stationary phases. The stereoselective biotransformation of halofantrine was determined using rat liver homogenates. (-)-Halofantrine is metabolized preferentially.

引用

页码：347 / 351

页数：5

共 8 条

[1] HALOFANTRINE - A REVIEW OF ITS ANTIMALARIAL ACTIVITY, PHARMACOKINETIC PROPERTIES AND THERAPEUTIC POTENTIAL [J].

BRYSON, HM ;

GOA, KL .

DRUGS, 1992, 43 (02) :236-258

[2] CHIRAL SEPARATION OF THE OPTICAL ISOMERS OF THE ANTIMALARIAL DRUG HALOFANTRINE [J].

CAMILLERI, P ;

DYKE, C ;

HOSSNER, F .

JOURNAL OF CHROMATOGRAPHY, 1989, 477 (02) :471-473

[3] RESOLUTION OF ANTI-MALARIAL AGENTS VIA COMPLEX-FORMATION WITH ALPHA-(2,4,5,7-TETRANITRO-9-FLUORENYLIDENEAMINOOXY)PROPIONIC ACID [J].

CARROLL, FI ;

BERRANG, B ;

LINN, CP .

JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (04) :326-330

[4] ION-PAIRED LIQUID-CHROMATOGRAPHIC METHOD FOR THE ANALYSIS OF BLOOD AND PLASMA FOR THE ANTIMALARIAL DRUG HALOFANTRINE AND ITS PUTATIVE MONO-DEBUTYLATED METABOLITE [J].

GAWIENOWSKI, M ;

BENET, LZ ;

FLECKENSTEIN, L ;

LIN, ET .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 430 (02) :412-419

[5] THE DETERMINATION OF THE ENANTIOMERS OF HALOFANTRINE AND MONODESBUTYLHALOFANTRINE IN PLASMA AND WHOLE-BLOOD USING SEQUENTIAL ACHIRAL CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

GIMENEZ, F ;

AUBRY, AF ;

FARINOTTI, R ;

KIRKLAND, K ;

WAINER, IW .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1992, 10 (2-3) :245-250

[6]

HOGEMANN A, 1990, ARZNEIMITTELFORSCH, V40-2, P1159

[7]

MILTON KA, 1988, J CHROMATOGR-BIOMED, V433, P339

[8] ANTI-MALARIAL ACTIVITIES OF VARIOUS 9-PHENANTHRENEMETHANOLS WITH SPECIAL ATTENTION TO WR-122,455 AND WR-171,669 [J].

SCHMIDT, LH ;

CROSBY, R ;

RASCO, J ;

VAUGHAN, D .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 14 (03) :292-314

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