MILLER-DIEKER LISSENCEPHALY GENE ENCODES A SUBUNIT OF BRAIN PLATELET-ACTIVATING-FACTOR

被引：429

作者：

HATTORI, M ^{[1
]}

ADACHI, H ^{[1
]}

TSUJIMOTO, M ^{[1
]}

ARAI, H ^{[1
]}

INOUE, K ^{[1
]}

机构：

[1] SUNTORY INST BIOMED RES,MISHIMA 618,OSAKA,JAPAN

来源：

NATURE | 1994年 / 370卷 / 6486期

关键词：

D O I：

10.1038/370216a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

PLATELET-ACTIVATING factor (PAF) is involved in a variety of biological and pathological processes(1) and PAF acetylhydrolase, which inactivates PAF by removing the acetyl group at the sn-2 position, is widely distributed in plasma and tissue cytosols(2,3). One isoform of PAP acetylhydrolase present in bovine brain cortex is a heterotrimer comprising subunits with relative molecular masses of 45K, 30K and 29K (ref. 4). We have now isolated the complementary DNA for the 45K subunit. Sequence analysis revealed a striking identity (99%) of the subunit with a protein encoded by the causative gene (LIS-1) for MiUer-Dieker lissencephaly(5), a human brain malformation manifested by a smooth cerebral surface and abnormal neuronal migration. This indicates that the LIS-1 gene product is a human homologue of the 45K subunit of intracellular PAF acetylhydrolase. Our results raise the possibility that PAF and PAF acetylhydrolase are important in the formation of the brain cortex during differentiation and development.

引用

页码：216 / 218

页数：3

共 18 条

[1] PLATELET-ACTIVATING-FACTOR (PAF) RECEPTOR IN RAT-BRAIN - PAF MOBILIZES INTRACELLULAR CA2+ IN HIPPOCAMPAL-NEURONS [J].