PREVALENCE OF SHIGELLA ENTEROTOXIN-1 AMONG SHIGELLA CLINICAL ISOLATES OF DIVERSE SEROTYPES

被引：64

作者：

NORIEGA, FR

LIAO, FM

FORMAL, SB

FASANO, A

LEVINE, MM

机构：

[1] Center for Vaccine Development, University of Maryland School of Medicine, Baltimore

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/infdis/172.5.1408

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Shigella enterotoxin 1 (ShET1) is a novel, iron-dependent, toxin encoded by chromosomal genes (set1), To determine the prevalence of this enterotoxin, 172 Shigella clinical isolates (and 10 enteroinvasive Escherichia coli [EIEC]) from distant areas worldwide, representing all 4 groups and 45 serotypes of Shigella, were screened for set1 by DNA colony hybridization and polymerase chain reaction amplification, set1 was present in all 22 Shigella flexneri 2a strains tested but was rare in isolates of other Shigella serotypes (3.3%, 5/150) and not found in EIEC (0/10). That ShET1 is found almost exclusively in S. flexneri 2a may help explain the epidemiologic predominance of this serotype in the developing world.

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页码：1408 / 1410

页数：3

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