THE MODIFYING INFLUENCE OF ANESTHESIA ON POSTOPERATIVE PROTEIN CATABOLISM

被引:6
作者
GIESECKE, K
KLINGSTEDT, C
LJUNGQVIST, O
HAGENFELDT, L
机构
[1] SODER SJUKHUSET,DEPT ANAESTHESIOL,S-11883 STOCKHOLM,SWEDEN
[2] KAROLINSKA HOSP,DEPT SURG,S-10401 STOCKHOLM,SWEDEN
[3] HUDDINGE HOSP,DEPT CLIN CHEM,S-14186 HUDDINGE,SWEDEN
关键词
METABOLISM; PROTEIN;
D O I
10.1093/bja/72.6.697
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We studied two groups of six patients scheduled for gastrointestinal surgery; they were allocated randomly to receive high- or low-dose fentanyl anaesthesia. The confounding effect of protein balance, before the trauma of surgery, on postoperative nitrogen excretion was controlled by standardized protein intake before operation, supplemented by adequate calories. The high-dose group had significantly lower stress levels during surgery, assessed by arterial blood concentrations of cortisone, adrenaline and glucose. After operation, protein catabolism was measured for 7 days. The high-dose group had significantly lower postoperative excretion of ammonia and slightly lower excretion of urea and 3-methylhistidine. Low-stress anaesthesia may thus diminish postoperative catabolism, which could be important in frail patients by reducing mortality, ICU resources, or both.
引用
收藏
页码:697 / 699
页数:3
相关论文
共 6 条
[1]  
ANAND KJS, 1987, LANCET, V1, P243
[2]   EPIDURAL ANALGESIA IMPROVES POSTOPERATIVE NITROGEN-BALANCE [J].
BRANDT, MR ;
FERNANDES, A ;
MORDHORST, R ;
KEHLET, H .
BRITISH MEDICAL JOURNAL, 1978, 1 (6120) :1106-1108
[3]  
GIESECKE J, 1988, BRIT J ANAESTH, V61, P652
[4]   PROTEIN AND AMINO-ACID METABOLISM DURING EARLY STARVATION AS REFLECTED BY EXCRETION OF UREA AND METHYLHISTIDINES [J].
GIESECKE, K ;
MAGNUSSON, I ;
AHLBERG, M ;
HAGENFELDT, L ;
WAHREN, J .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1989, 38 (12) :1196-1200
[5]   FENTANYL AND THE METABOLIC RESPONSE TO SURGERY [J].
HALL, GM .
BRITISH JOURNAL OF ANAESTHESIA, 1980, 52 (06) :561-562
[6]  
ROIZEN MF, 1988, ANESTHESIOLOGY, V68, P482