CD30, TH2 CYTOKINES AND HIV-INFECTION - A COMPLEX AND FASCINATING LINK

被引：145

作者：

DELPRETE, G ^{[1
]}

MAGGI, E ^{[1
]}

PIZZOLO, G ^{[1
]}

ROMAGNANI, S ^{[1
]}

机构：

[1] UNIV VERONA,DIV HEMATOL,I-37134 VERONA,ITALY

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 02期

关键词：

D O I：

10.1016/0167-5699(95)80092-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD30 is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily, and was originally described as a marker of Hodgkin's and Reed-Sternberg cells in Hodgkin's lymphoma. CD30 is preferentially expressed on CD4(+) and CD8(+) T-cell clones that produce T helper 2 (Th2)-type cytokines, and is also released in a soluble form by these cells. Elevated serum levels of soluble (s) CD30 have been found in some conditions in which a pathogenic role for Th2 cells has been suggested, such as atopy, Omenn's syndrome, systemic lupus erythematosus, as well as following infection with measles virus or human immunodeficiency virus (HIV). Here, Gianfranco Del Prete and colleagues suggest a complex and fascinating link between the expression and release of CD30, and the immunopathogenesis of HIV infection.

引用

页码：76 / 80

页数：5

共 40 条

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