LUTEOLYTIC PROSTAGLANDINS SYNTHESIS AND BIOLOGICAL-ACTIVITY

被引：9

作者：

BARTMANN, W

BECK, G

LERCH, U

TEUFEL, H

SCHOLKENS, B

机构：

[1] Hoechst AG

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 02期

关键词：

D O I：

10.1016/0090-6980(79)90050-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analogues of PGF2α with enhanced luteolytic activity were synthesized using the Corey synthesis. The luteolytic activity of the new prostaglandins was tested in the hamster. In addition the smooth muscle activity of the new compounds was compared with that of PGA2 on the longitudinal strip of rat stomach fundus. Structure-activity relationships in the new series of 17,18,19,20-tetranor-16-thienyl-oxy-PGF2α are discussed. © 1979.

引用

页码：301 / 311

页数：11

共 16 条

[1] SEQUENCE OF EARLY STEPS IN METABOLISM OF PROSTAGLANDIN-E1 [J].