CORTICOSTEROIDS STIMULATE HEPATITIS-B VIRUS-DNA, MESSENGER-RNA AND PROTEIN-PRODUCTION IN A STABLE EXPRESSION SYSTEM

被引：58

作者：

TURKASPA, R

LAUB, O

机构：

[1] HADASSAH UNIV HOSP,LIVER UNIT,IL-91120 JERUSALEM,ISRAEL

[2] WEIZMANN INST SCI,DEPT GENET,IL-76100 REHOVOT,ISRAEL

来源：

JOURNAL OF HEPATOLOGY | 1990年 / 11卷 / 01期

关键词：

D O I：

10.1016/0168-8278(90)90268-V

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effect of corticosteroids (Dexamethasone) on hepatitis B virus was investigated in human hepatoblastoma cells stable transfected with recombinant HBV DNA. Dexamethasone was found to cause elevation of HBsAg, HBeAg and viral DNA production. HBV poly(A)+ RNA was significantly increased in cells treated with Dexamethasone. Furthermore, pulse labelled nuclear HBV RNA was also stimulated by Dexamethasone. These findings, suggest that corticosteroids enhance expression of viral gene products by stimulating HBV transcription. © 1990.

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页码：34 / 36

页数：3

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