SUPPRESSION OF SOMATOSTATIN LEVELS IN THE HEPATIC PORTAL AND SYSTEMIC PLASMA OF THE RAT BY SYNTHETIC HUMAN PANCREATIC POLYPEPTIDE

被引：26

作者：

ARIMURA, A

MEYERS, CA

CASE, WL

MURPHY, WA

SCHALLY, AV

机构：

[1] TULANE UNIV,SCH MED,DEPT ANAT,NEW ORLEANS,LA 70112

[2] VET ADM HOSP,ENDOCRINE & POLYPEPTIDE LAB,NEW ORLEANS,LA 70140

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)91865-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intravenous administration of synthetic human pancreatic polypeptide (hPP) with 36 amino acid residues significantly decreased immunoreactive somatostatin levels in both hepatic portal and systemic plasma in anesthetized rats. The effect of hPP on plasma somatostatin levels is acute. The results suggest that hPP may have a role in controlling somatostatin secretion from the gut and pancreas. © 1979.

引用

页码：913 / 918

页数：6

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