PLATELET-FUNCTION AFTER INTRAMUSCULAR DICLOFENAC

被引：60

作者：

POWER, I

CHAMBERS, WA

GREER, IA

RAMAGE, D

SIMON, E

机构：

[1] CITY HOSP EDINBURGH,EDINBURGH EH10 5SB,MIDLOTHIAN,SCOTLAND

[2] UNIV EDINBURGH,CTR REPROD BIOL,DEPT OBSTET & GYNAECOL,EDINBURGH EH3 9EW,SCOTLAND

来源：

ANAESTHESIA | 1990年 / 45卷 / 11期

关键词：

Analgesics; diclofenac; Blood; coagulation;

D O I：

10.1111/j.1365-2044.1990.tb14618.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

A randomised double‐blind controlled study was performed to examine the effect of diclofenac on skin bleeding time and in vitro whole blood platelet aggregation. Twenty thoracotomy patients were studied; 10 were given diclofenac 75 mg intramuscularly at induction of anaesthesia, and 10 formed a control group. Skin bleeding times and platelet aggregation tests were performed the day before and repeated one hour after induction of anaesthesia. Diclofenac prolonged skin bleeding time and reduced platelet aggregation. There were no significant changes in the control group. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：916 / 919

页数：4

共 15 条

[1]

BLACKWELL GJ, 1978, BRIT J PHARMACOL, V64, pP436

[2]

BRICKER SRW, 1987, EUR J ANAESTH, V4, P429

[3]

BUCHANAN JM, 1988, ANN ROY COLL SURG, V70, P332

[4] INDOMETHACIN AS AN ANALGESIC AFTER HYSTERECTOMY [J].

ENGEL, C ;

LUND, B ;

KRISTENSEN, SS ;

AXEL, C ;

NIELSEN, JB .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1989, 33 (06) :498-501

[5]

FOX SC, 1982, THROMB HAEMOSTASIS, V48, P327

[6] INHIBITION OF PLATELET-AGGREGATION IN WHOLE-BLOOD BY ADRENOCEPTOR ANTAGONISTS [J].

GREER, IA ;

WALKER, JJ ;

CALDER, AA ;

FORBES, CD .

THROMBOSIS RESEARCH, 1985, 40 (05) :631-643

[7]

Ivy AC, 1941, J LAB CLIN MED, V26, P1812

[8] A METHOD FOR QUANTITATING PLATELET-AGGREGATION AND ANALYZING DRUG-RECEPTOR INTERACTIONS ON PLATELETS IN WHOLE-BLOOD INVITRO [J].

LUMLEY, P ;

HUMPHREY, PPA .

JOURNAL OF PHARMACOLOGICAL METHODS, 1981, 6 (02) :153-166

[9] STANDARDIZED NORMAL IVY BLEEDING TIME AND ITS PROLONGATION BY ASPIRIN [J].

MIELKE, CH ;

KANESHIRO, MM ;

MAHER, IA ;

WEINER, JM ;

RAPAPORT, SI .

BLOOD-THE JOURNAL OF HEMATOLOGY, 1969, 34 (02) :204-+

[10]

RORARIUS M, 1985, ANN CLIN RES, V17, P306

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