IRON TRANSPORT MEDIATED DRUG DELIVERY SYSTEMS - SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SPERMIDINE-BASED AND LYSINE-BASED SIDEROPHORE-BETA-LACTAM CONJUGATES

被引：37

作者：

MCKEE, JA ^{[1
]}

SHARMA, SK ^{[1
]}

MILLER, MJ ^{[1
]}

机构：

[1] UNIV NOTRE DAME,DEPT CHEM & BIOCHEM,NOTRE DAME,IN 46556

来源：

BIOCONJUGATE CHEMISTRY | 1991年 / 2卷 / 04期

关键词：

D O I：

10.1021/bc00010a013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Conceptually, the penetration of beta-lactam antibiotics through the bacterial cell wall can be enhanced by utilizing various active transport systems such as the active iron-transport system that exists in bacteria. Several beta-lactam-siderophore analogue (microbial iron chelators) conjugates were prepared to investigate this approach. Thus, monocyclic (oxamazin) and bicyclic (carbacephalosporin) beta-lactams were separately linked to dihydroxybenzoyl derivatives of spermidine and lysine. The antibacterial activity of these conjugates has been investigated and the potential use of the iron-transport system as a drug-delivery system is discussed.

引用

页码：281 / 291

页数：11

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