LONG-TERM AMPHETAMINE TREATMENT DECREASES BRAIN-SEROTONIN METABOLISM - IMPLICATIONS FOR THEORIES OF SCHIZOPHRENIA

被引：70

作者：

TRULSON, ME

JACOBS, BL

机构：

[1] Program of Neuroscience, Department of Psychology, Princeton University, Princeton

来源：

SCIENCE | 1979年 / 205卷 / 4412期

关键词：

D O I：

10.1126/science.572992

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-term amphetamine administration to cats (a mean of 8.75 milligrams per kilogram twice daily for 10 days) produced large decreases (40 to 67 percent in serotonin and its major metabolite, 5-hydroxyindoleacetic acid, in all brain regions examined. This treatment also produced several behaviors that are dependent on depressed central serotonergic neurotransmission, and which normally are elicited exclusively by hallucinogenic drugs. Short-term amphetamine administration (15 mg/kg) did not produce these behaviors and resulted in small decreases in brain serotonin and no change in 5-hydroxyindoleacetic acid. These data are discussed in the context of monoamine theories of schizophrenia. Copyright © 1979 AAAS.

引用

页码：1295 / 1297

页数：3

共 45 条

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