TOPICAL OFLOXACIN IN THE TREATMENT OF PSEUDOMONAS KERATITIS IN A RABBIT MODEL

被引：14

作者：

GRITZ, DC ^{[1
]}

MCDONNELL, PJ ^{[1
]}

LEE, TY ^{[1
]}

TANGLIU, D ^{[1
]}

HUBBARD, BB ^{[1
]}

GWON, A ^{[1
]}

机构：

[1] UNIV SO CALIF,SCH MED,DOHENY EYE INST,1355 SAN PABLO ST,LOS ANGELES,CA 90033

来源：

CORNEA | 1992年 / 11卷 / 02期

关键词：

ANIMAL MODEL; ANTIBIOTICS; KERATITIS; OFLOXACIN; PSEUDOMONAS; TOBRAMYCIN;

D O I：

10.1097/00003226-199203000-00008

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Ofloxacin, a new quinolone antibiotic with a broad spectrum of activity, is very effective against Pseudomonas aeruginosa in vitro. Its effectiveness was studied in a rabbit model of tobramycin-sensitive P. aeruginosa. Treatment groups received either vehicle, tobramycin 0.3%, or ofloxacin 0.3%. Twelve hours of treatment decreased the bacterial counts from a mean of 2.2 +/- 0.7 x 10(6) colony forming units (cfu) per cornea in the vehicle group to means of 513 +/- 670 and 435 +/- 524 cfu in the tobramycin and ofloxacin groups, respectively. This decrease in bacterial counts was statistically significant (p = 0.001 for tobramycin and ofloxacin each compared with control, p = 0.86 for tobramycin compared with ofloxacin). After seven days, all antibiotic-treated corneas were sterile and the epithelial defects healed at comparable rates. Aqueous humor drug levels were higher in infected eyes without an intact epithelium (p = 0.02); in eyes with intact epithelium, concentrations of ofloxacin were higher than were those of tobramycin (p = 0.002). In this animal model, ofloxacin proved to be an effective antibiotic with no evidence of toxicity.

引用

页码：143 / 147

页数：5