TOPICAL OFLOXACIN IN THE TREATMENT OF PSEUDOMONAS KERATITIS IN A RABBIT MODEL

被引:14
作者
GRITZ, DC [1 ]
MCDONNELL, PJ [1 ]
LEE, TY [1 ]
TANGLIU, D [1 ]
HUBBARD, BB [1 ]
GWON, A [1 ]
机构
[1] UNIV SO CALIF,SCH MED,DOHENY EYE INST,1355 SAN PABLO ST,LOS ANGELES,CA 90033
关键词
ANIMAL MODEL; ANTIBIOTICS; KERATITIS; OFLOXACIN; PSEUDOMONAS; TOBRAMYCIN;
D O I
10.1097/00003226-199203000-00008
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Ofloxacin, a new quinolone antibiotic with a broad spectrum of activity, is very effective against Pseudomonas aeruginosa in vitro. Its effectiveness was studied in a rabbit model of tobramycin-sensitive P. aeruginosa. Treatment groups received either vehicle, tobramycin 0.3%, or ofloxacin 0.3%. Twelve hours of treatment decreased the bacterial counts from a mean of 2.2 +/- 0.7 x 10(6) colony forming units (cfu) per cornea in the vehicle group to means of 513 +/- 670 and 435 +/- 524 cfu in the tobramycin and ofloxacin groups, respectively. This decrease in bacterial counts was statistically significant (p = 0.001 for tobramycin and ofloxacin each compared with control, p = 0.86 for tobramycin compared with ofloxacin). After seven days, all antibiotic-treated corneas were sterile and the epithelial defects healed at comparable rates. Aqueous humor drug levels were higher in infected eyes without an intact epithelium (p = 0.02); in eyes with intact epithelium, concentrations of ofloxacin were higher than were those of tobramycin (p = 0.002). In this animal model, ofloxacin proved to be an effective antibiotic with no evidence of toxicity.
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页码:143 / 147
页数:5
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