HETEROGENEITY IN HUMAN SOLUBLE GUANYLATE-CYCLASE DUE TO ALTERNATIVE SPLICING

被引：28

作者：

CHHAJLANI, V ^{[1
]}

FRANDBERG, PA ^{[1
]}

AHLNER, J ^{[1
]}

AXELSSON, KL ^{[1
]}

WIKBERG, JES ^{[1
]}

机构：

[1] LINKOPING UNIV,DEPT PHARMACOL,S-58185 LINKOPING,SWEDEN

来源：

FEBS LETTERS | 1991年 / 290卷 / 1-2期

关键词：

HUMAN GUANYLATE CYCLASE; POLYMERASE CHAIN REACTION; CDNA; ALTERNATIVE SPLICING;

D O I：

10.1016/0014-5793(91)81248-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.

引用

页码：157 / 158

页数：2

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