CRYO-EM OF THE NATIVE STRUCTURE OF THE CALCIUM RELEASE CHANNEL RYANODINE RECEPTOR FROM SARCOPLASMIC-RETICULUM

被引：65

作者：

RADERMACHER, M ^{[1
]}

WAGENKNECHT, T ^{[1
]}

GRASSUCCI, R ^{[1
]}

FRANK, J ^{[1
]}

INUI, M ^{[1
]}

CHADWICK, C ^{[1
]}

FLEISCHER, S ^{[1
]}

机构：

[1] VANDERBILT UNIV, DEPT MOLEC BIOL, NASHVILLE, TN 37235 USA

来源：

BIOPHYSICAL JOURNAL | 1992年 / 61卷 / 04期

关键词：

D O I：

10.1016/S0006-3495(92)81900-8

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The native structure of the calcium release channel (ryanodine receptor) from rabbit skeletal muscle has been analyzed in two dimensions from electron micrographs of frozen hydrated specimens. Within a resolution of 3.0 nm there is excellent agreement between the structure as seen in vitreous water and in negative stained specimens. Features seen in the three-dimensional reconstruction of the negatively stained channel can be identified in the projection of the unstained receptor.

引用

页码：936 / 940

页数：5

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