AN OVERVIEW OF THE RESULTS OF TESTING OF KNOWN OR SUSPECTED ANEUGENS USING MAMMALIAN-CELLS INVITRO

被引：34

作者：

NATARAJAN, AT

机构：

[1] MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Leiden

来源：

MUTATION RESEARCH | 1993年 / 287卷 / 01期

关键词：

ANEUPLOIDY INDUCTION; MAMMALIAN CELLS; INVITRO;

D O I：

10.1016/0027-5107(93)90150-E

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ten known or suspected aneugens were analyzed in a variety of in vitro mammalian cell cultures using different endpoints which included: micronuclei, kinetochore-positive micronuclei in binucleated cells, changes in the number of chromosomes or aberrations of mitosis and division. Human lymphocytes, human diploid fibroblasts and Chinese hamster transformed cells were used as target cells. The relative merits of different in vitro test systems employed are briefly discussed here.

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页码：113 / 118

页数：6

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