ISOLATION OF CIS-[PTCL(NH3)2(H2O)](CLO4), THE MONOHYDRATED FORM OF THE ANTITUMOR DRUG CISPLATIN, USING CATION-EXCHANGE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：13

作者：

GONNET, F ^{[1
]}

LEMAIRE, D ^{[1
]}

KOZELKA, J ^{[1
]}

CHOTTARD, JC ^{[1
]}

机构：

[1] LAB CHIM & BIOCHIM PHARMACOL & TOXICOL,CNRS,URA 400,45 RUE ST PERES,F-75270 PARIS 06,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 648卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)83312-G

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel procedure allowing a quantitative separation of the anti-tumour drug cisplatin and its hydration products, based on cation-exchange high-performance liquid chromatography, is presented. Thanks to this procedure, the monohydrated form of cisplatin, cis-[PtCl(NH3)2(H2O]+, which is possibly the principal species reacting in vivo with DNA and thus responsible for the anti-tumour activity, could be isolated and characterized in the pure state for the first time.

引用

页码：279 / 282

页数：4

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