GAP JUNCTIONAL INTERCELLULAR COMMUNICATION AND CELL-PROLIFERATION DURING RAT-LIVER CARCINOGENESIS

被引：44

作者：

YAMASAKI, H

KRUTOVSKIKH, V

MESNIL, M

COLUMBANO, A

TSUDA, H

ITO, N

机构：

[1] UNIV CAGLIARI,INST EXPTL PATHOL,CAGLIARI,ITALY

[2] FUJITA HLTH UNIV,DEPT PATHOL,TOYO,JAPAN

[3] NAGOYA CITY UNIV,DEPT PATHOL,NAGOYA,AICHI,JAPAN

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1993年 / 101卷

关键词：

D O I：

10.2307/3431867

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

During multistage liver carcinogenesis, there is a sequential decrease in gap junctional intercellular communication (GJIC), associated with reduced expression of a major liver gap-junction protein (connexin 32). There are also several lines of evidence indicating that the induction of cell proliferation plays an important role during liver carcinogenesis. The relationship between GJIC and cell proliferation and their roles in liver carcinogenesis are not yet known. Results from various experiments suggest that there is a close relationship between the inhibition of GJIC and stimulation of liver cell proliferation. However, our results also suggest that different stimuli may affect cell proliferation and GJIC differentially by different mechanisms.

引用

页码：191 / 197

页数：7

共 41 条

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