CHROMOSOMAL LOCALIZATION OF THE HUMAN GENE ENCODING THE 51-KDA SUBUNIT OF MITOCHONDRIAL COMPLEX-I (NDUFV1) TO 11Q13

被引：31

作者：

ALI, ST

DUNCAN, AMV

SCHAPPERT, K

HENG, HHQ

TSUI, LC

CHOW, W

ROBINSON, BH

机构：

[1] HOSP SICK CHILDREN, RES INST, TORONTO M5G 1X8, ON, CANADA

[2] UNIV TORONTO, DEPT GENET, RES INST, TORONTO, ON, CANADA

[3] UNIV TORONTO, DEPT BIOCHEM, TORONTO, ON, CANADA

[4] UNIV TORONTO, DEPT PEDIAT, TORONTO, ON, CANADA

[5] QUEENS UNIV, DEPT PATHOL, KINGSTON K7L 3N6, ON, CANADA

[6] KINGSTON GEN HOSP, KINGSTON, ON, CANADA

来源：

GENOMICS | 1993年 / 18卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1493

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The 51-kDa flavoprotein subunit of mitochondrial NADH:ubiquinone oxidoreductase (Complex I) [NADH dehydrogenase (ubiquinone), flavoprotein 1 (51 kDa); EC 1.6.5.3] plays an important role in the formation of the NADH-binding site and is believed to be the principal site of entry for electrons donated by NADH into the respiratory chain. Human cDNA fragments of the 51-kDa protein were generated by polymerase chain reaction and used to localize the gene (NDUFV1) for this subunit to 11q13 by two separate techniques. This region of the human genome is strongly implicated in a number of different forms of cancer. © 1993 by Academic Press, Inc.

引用

页码：435 / 439

页数：5

共 30 条

[1] URF6, LAST UNIDENTIFIED READING FRAME OF HUMAN MTDNA, CODES FOR AN NADH DEHYDROGENASE SUBUNIT
CHOMYN, A
CLEETER, MWJ
RAGAN, CI
RILEY, M
DOOLITTLE, RF
ATTARDI, G
[J]. SCIENCE, 1986, 234 (4776) : 614 - 618
[2] DETERMINATION OF THE CDNA SEQUENCE FOR THE HUMAN MITOCHONDRIAL 75-KDA FE-S PROTEIN OF NADH-COENZYME-Q REDUCTASE
CHOW, W
RAGAN, I
ROBINSON, BH
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 201 (03): : 547 - 550
[3] AN UNUSUAL PATIENT WITH THE NEONATAL MARFAN PHENOTYPE AND MITOCHONDRIAL COMPLEX-I DEFICIENCY
CHRISTODOULOU, J
PETROVABENEDICT, R
ROBINSON, BH
JAY, V
CLARKE, JTR
[J]. EUROPEAN JOURNAL OF PEDIATRICS, 1993, 152 (05) : 428 - 432
[4] LOCALIZATION OF THE HUMAN 75-KDAL FE-S PROTEIN OF NADH-COENZYME-Q REDUCTASE GENE (NDUFS1) TO 2Q33-]Q34
DUNCAN, AMV
CHOW, W
ROBINSON, BH
[J]. CYTOGENETICS AND CELL GENETICS, 1992, 60 (3-4): : 212 - 213
[5] LOCALIZATION OF SINGLE COPY DNA-SEQUENCES ON G-BANDED HUMAN-CHROMOSOMES BY INSITU HYBRIDIZATION
HARPER, ME
SAUNDERS, GF
[J]. CHROMOSOMA, 1981, 83 (03) : 431 - 439
[6] MODES OF DAPI BANDING AND SIMULTANEOUS INSITU HYBRIDIZATION
HENG, HHQ
TSUI, LC
[J]. CHROMOSOMA, 1993, 102 (05) : 325 - 332
[7] HIGH-RESOLUTION MAPPING OF MAMMALIAN GENES BY INSITU HYBRIDIZATION TO FREE CHROMATIN
HENG, HHQ
SQUIRE, J
TSUI, LC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) : 9509 - 9513
[8] LOCATION ON CHROMOSOME-15 OF THE GENE DEFECT CAUSING MARFAN-SYNDROME
KAINULAINEN, K
PULKKINEN, L
SAVOLAINEN, A
KAITILA, I
PELTONEN, L
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (14) : 935 - 939
[9] LAMMIE GA, 1991, ONCOGENE, V6, P439
[10] HIGH-RESOLUTION CHROMOSOMAL LOCALIZATION OF THE BETA-GENE OF THE HUMAN BETA-GLOBIN GENE-COMPLEX BY INSITU HYBRIDIZATION
LIN, CC
DRAPER, PN
DEBRAEKELEER, M
[J]. CYTOGENETICS AND CELL GENETICS, 1985, 39 (04): : 269 - 274

← 1 2 3 →