CATALYTIC ASYMMETRIC MICHAEL ADDITION OF NITROALKANE TO ENONE AND ENAL

被引：121

作者：

YAMAGUCHI, M

SHIRAISHI, T

IGARASHI, Y

HIRAMA, M

机构：

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 44期

关键词：

D O I：

10.1016/0040-4039(94)88290-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

L-Proline rubidium salt catalyzes the asymmetric Michael addition of nitroalkanes to enones and an enal. (R)-Adducts were obtained from cyclic (Z)-enones and (S)-adducts from acyclic (E)-enones. Bu(3)SnH treatment of the products replaced the nitro group with hydrogen atom. The overall transformation allows the asymmetric alkylation of enones at the beta-carbon atom.

引用

页码：8233 / 8236

页数：4

共 23 条

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