THE EPIDERMAL GROWTH-FACTOR TRANSFORMING GROWTH-FACTOR-ALPHA FAMILY AND THEIR RECEPTORS

被引:38
作者
BROWN, KD
机构
[1] Babraham Institute, Cambridge, Babraham
关键词
EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR-ALPHA; AMPHIREGULIN; BETACELLULIN; HEPARIN-BINDING; NEUREGULINS; RECEPTOR TYROSINE KINASES; CELL SIGNALING PATHWAYS; CYTOKINES;
D O I
10.1097/00042737-199510000-00002
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Cytokines and growth factors act as intercellular signalling molecules which control cellular functions during development and in response to injury or infection. The epidermal growth factor (EGF) family is an expanding group of structurally related polypeptides that regulate cell proliferation, migration and differentiation, via tyrosine kinase receptors on target cells. This chapter reviews recent developments in the characterization of EGF family members and their receptors.
引用
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页码:914 / 922
页数:9
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共 58 条
[1]  
Lemmon M.A., Schlessinger J., Regulation of signal-transduction and signal diversity by receptor oligomerization, Trends Biochem Sci, 19, pp. 459-463, (1994)
[2]  
Heldin C.H., Dimerization of cell-surface receptors in signaltransduction, Cell, 80, pp. 213-223, (1995)
[3]  
Van Der Geer P., Hunter T., Lindberg R.A., Receptor protein-tyrosine kinases and their signal-transduction pathways, Annu Rev Cell Biol, 10, pp. 251-337, (1994)
[4]  
Peles E., Yarden Y., Neu and its ligands: From an oncogene to neural factors, Bioessays, 15, pp. 815-824, (1993)
[5]  
Ben-Baruch N., Yarden Y., Neu differentiation factors: A family of alternatively spliced neuronal and mesenchymal factors, Proc Soc Exp Biol Med, 206, pp. 221-227, (1994)
[6]  
Wen D., Suggs S.V., Karunagaran D., Liu N., Cupples R.L., Luo Y., Et al., Structural and functional aspects of the multiplicity of neu differentiation factors, Mol Cell Biol, 14, pp. 1909-1919, (1994)
[7]  
Toyoda H., Komurasaki T., Uchida D., Takayama Y., Isobe T., Okuyama T., Et al., Epiregulin: A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes, J Biol Chem, 270, pp. 7495-7500, (1995)
[8]  
Rutledge B.J., Zhang K., Bier E., Jan Y.N., Perrimon N., The, Genes Dev, 6, pp. 1503-2151, (1992)
[9]  
Neuman-Silberberg F.S., Schupbach T., The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGFα-like protein, Cell, 75, pp. 165-174, (1993)
[10]  
Hill R.J., Sternberg P.W., The gene lin-3 encodes an inductive, Elegans, 358, pp. 470-476, (1992)