POLYPEPTIDES .8. VARIATIONS OF ASPARTYL POSITION IN C-TERMINAL TETRAPEPTIDE AMIDE SEQUENCE OF GASTRINS

被引：30

作者：

GREGORY, H

MORLEY, JS

SMITH, JM

SMITHERS, MJ

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1968年 / 06期

关键词：

D O I：

10.1039/j39680000715

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis is described of analogues of L-tryptophyl-L-methionyl-L- aspartyl-L-phenylalanine amide (the C-terminal sequence of the gastrins), and its N-benzyloxycarbonyl or N-t-butoxycarbonyl derivatives, wherein the aspartyl residue has undergone replacement by alanyl, β-aspartyl, asparaginyl, cysteinyl, glutamyl, glycyl, lysyl, norvalyl, ornithyl, seryl, threonyl, and other amino-acyl residues.

引用

收藏

页码：715 / +

页数：1

相关论文

共 23 条

[1] USE OF ESTERS OF N-HYDROXYSUCCINIMIDE IN PEPTIDE SYNTHESIS [J].

ANDERSON, GW ;

CALLAHAN, FM ;

ZIMMERMAN, JE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (09) :1839-+

[2]

BAER E, 1962, J BIOL CHEM, V237, P1449

[3] THE ENZYMIC RESOLUTION OF BETA-METHYLASPARTIC ACID WITH ACYLASE-II [J].

BENOITON, L ;

BIRNBAUM, SM ;

WINITZ, M ;

GREENSTEIN, JP .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 81 (02) :434-438

[4]

BENTLEY PH, 1964, J CHEM SOC, VS, P6130

[5] Syntheses with glucosamine. [J].

Bergmann, M ;

Zervas, L .

BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1931, 64 :975-980

[6] POLYPEPTIDES .V. USE OF T-BUTYL 2,4,5-TRICHLOROPHENYL CARBONATE IN SYNTHESIS OF N-T-BUTOXYCARBONYL AMINO-ACIDS AND THEIR 2,4,5-TRICHLOROPHENYL ESTERS [J].

BROADBENT, W ;

MORLEY, JS ;

STONE, BE .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1967, (24) :2632-+

[7] TERTIARY BUTYL GROUP AS A BLOCKING AGENT FOR HYDROXYL, SULFHYDRYL AND AMIDO FUNCTIONS IN PEPTIDE SYNTHESIS [J].

CALLAHAN, FM ;

PAUL, R ;

ANDERSON, GW ;

ZIMMERMAN, JE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (02) :201-&

[8] POLYPEPTIDES .3. SYNTHESIS OF C-TERMINAL TETRAPEPTIDE SEQUENCE OF GASTRIN ITS OPTICAL ISOMERS AND ACYLATED DERIVATIVES [J].

DAVEY, JM ;

LAIRD, AH ;

MORLEY, JS .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1966, (05) :555-&

[9] THE PREPARATION OF BETA-AMINOGLUTARIC ACID AND BETA-AMINOADIPIC ACID [J].

FEUER, H ;

SWARTS, WA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (20) :5427-5428

[10]

Fruton JS, 1942, J BIOL CHEM, V145, P253