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The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis

被引：152
作者：
Sharma, Mithun [1 ]
Mitnala, Shasikala [2 ]
Vishnubhotla, Ravi K. [2 ,3 ]
Mukherjee, Rathin [4 ]
Reddy, Duvvur N. [5 ]
Rao, Padaki N. [6 ]
机构：
[1] Asian Inst Gastroenterol, Dept Hepatol & Nutr, Hyderabad, Telangana, India
[2] Inst Basic Sci & Translat Res, Res Labs, Hyderabad, Telangana, India
[3] Asian Inst Gastroenterol, Asian Healthcare Fdn, Dept Genet, Hyderabad, Telangana, India
[4] Asian Inst Gastroenterol, Asian Healthcare Fdn, Dept Mol Biol, Hyderabad, Telangana, India
[5] Asian Inst Gastroenterol, Asian Healthcare Fdn, Dept Gastroenterol, Hyderabad, Telangana, India
[6] Asian Inst Gastroenterol, Asian Healthcare Fdn, Dept Hepatol & Nutr, Hyderabad, Telangana, India
来源：
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY | 2015年 / 5卷 / 02期
关键词：
adiponectin; cytokines; gut microbiota; lipotoxicity; PNPLA3;
D O I：
10.1016/j.jceh.2015.02.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Nonalcoholic fatty liver (NAFL) is an emerging global epidemic which progresses to nonalcoholic steatohepatitis (NASH) and cirrhosis in a subset of subjects. Various reviews have focused on the etiology, epidemiology, pathogenesis and treatment of NAFLD. This review highlights specifically the triggers implicated in disease progression from NAFL to NASH. The integrating role of genes, dietary factors, innate immunity, cytokines and gut microbiome have been discussed.
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页码：147 / 158
页数：12
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