STRUCTURES OF [M-44]+ IONS IN THE ELECTRON-IMPACT AND FAST ATOM BOMBARDMENT MASS-SPECTRA OF THE BETA-BLOCKER NIPRADILOL WITH A NITRATE ESTER GROUP

被引：12

作者：

YONEDA, M ^{[1
]}

TSUJIMOTO, K ^{[1
]}

OHASHI, M ^{[1
]}

SHIRATSUCHI, M ^{[1
]}

OHKAWA, Y ^{[1
]}

机构：

[1] KOWA CO LTD,TOKYO RES LABS,HIGASHI MURAYAMA,TOKYO 189,JAPAN

来源：

ORGANIC MASS SPECTROMETRY | 1990年 / 25卷 / 03期

关键词：

D O I：

10.1002/oms.1210250305

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both electron impact (EI) and fast atom bombardment (liquid secondary ion mass spectrometry) (FAB(LSIMS)) spectra of tbe antihypertensive drug nipradilol (3,4‐dihydro‐8‐(2‐hydroxy‐3‐isopropylamino)propoxy‐3‐nitroxy‐2 H‐l‐benzopyran) and it analogues exhibit intense [M ‐ 44]+ peaks. However, high‐resolution measurements and tandem mass spectrometric techniques clarified that the composition of the ion produced by EI is [M‐C2H4O]+, whereas that of the ion produced by FAB(LSIMS) is [M ‐ NO2 + 2H]+. FAB collision‐activated dissociation‐tandem mass spectrometry revealed that the structure of the latter ion corresponds to the MH+ of the hydrolysis product of the nitrate ester group. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：146 / 150

页数：5

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