CHARACTERIZATION BY FTIR SPECTROSCOPY OF THE OLIGORIBONUCLEOTIDE DUPLEXES R(A-U)6 AND R(A-U)8

被引：48

作者：

LIQUIER, J

AKHEBAT, A

TAILLANDIER, E

CEOLIN, F

DINH, TH

IGOLEN, J

机构：

[1] UNIV PARIS NORD,CSSB LAB,CNRS,URA 1430,74 RUE MARCEL CACHIN,F-93012 BOBIGNY,FRANCE

[2] INST PASTEUR,CNRS,URA 487,UNITE CHIM ORGAN,F-75724 PARIS 15,FRANCE

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 1991年 / 47卷 / 02期

关键词：

D O I：

10.1016/0584-8539(91)80089-2

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Fourier transform infrared spectroscopy has been used to characterize the helical conformation of double stranded oligoribonucleotides r(A-U)6 and r(A-U)8 in solution. As expected the oligoribonucleotides are found to adopt in solution an A family type conformation. The simultaneous study of a series of duplexes containing A, T or U bases combined either with riboses or deoxyriboses allows us to propose a set of infrared marker bands allowing to distinguish between C2' endo/anti and C3' endo/anti conformers of dA, dT, rA and rU nucleosides in nucleic acids.

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页码：177 / 186

页数：10

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