EVIDENCE THAT BOTH LONG-ACTING THYROID-STIMULATOR AND LONG-ACTING THYROID STIMULATOR-PROTECTOR STIMULATE THE HUMAN THYROID-GLAND

被引：12

作者：

HOLMES, SD ^{[1
]}

DIRMIKIS, SM ^{[1
]}

MARTIN, TJ ^{[1
]}

MUNRO, DS ^{[1
]}

机构：

[1] UNIV SHEFFIELD,DEPT CHEM PATHOL,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

JOURNAL OF ENDOCRINOLOGY | 1979年 / 80卷 / 02期

关键词：

D O I：

10.1677/joe.0.0800215

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid-stimulating immunoglobulins were prepared from two potent sera, one contained long-acting thyroid stimulator (LATS) and the other contained both LATS and LATS-protector (LATS-P). The potencies of the immunoglobulin G (IgG) preparations were estimated in the McKenzie assay. The accumulation of cyclic AMP in mouse thyroid lobes was stimulated only by LATS-IgG;LATS-P-IgG was inactive. In contrast, both LATS-IgG and LATS-P-IgG were equally effective in slices of human thyroid.

引用

页码：215 / 221

页数：7

共 23 条

[1]

ADAMS DD, 1975, LANCET, V1, P1201

[2] STIMULATION OF HUMAN THYROID BY INFUSIONS OF PLASMA CONTAINING LATS PROTECTOR [J].

ADAMS, DD ;

FASTIER, FN ;

HOWIE, JB ;

KENNEDY, TH ;

KILPATRICK, JA ;

STEWART, RDH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1974, 39 (05) :826-832

[3] OCCURRENCE IN THYROTOXICOSIS OF A GAMMA GLOBULIN WHICH PROTECTS LATS FRON NEUTRALIZATION BY AN EXTRACT OF THYROID GLAND [J].

ADAMS, DD ;

KENNEDY, TH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1967, 27 (02) :173-+

[4]

ADAMS DD, 1976, AUST NZ J MED, V6, P300, DOI 10.1111/imj.1976.6.4.300

[5] CORRELATION BETWEEN LONG-ACTING THYROID-STIMULATOR PROTECTOR LEVEL AND THYROID I-131 UPTAKE IN THYROTOXICOSIS [J].

ADAMS, DD ;

KENNEDY, TH ;

STEWART, RDH .

BRITISH MEDICAL JOURNAL, 1974, 2 (5912) :199-201

[6]

Adams DD., 1956, PROC U OTAGO MED SCH, V34, P11

[7] BREAD - DIET FOR USE IN MCKENZIE BIOASSAY [J].

BROADHEAD, GD ;

DIRMIKIS, SM ;

HUMPHRIES, H ;

JUSTICE, SK ;

LOY, G ;

SMITH, T .

JOURNAL OF ENDOCRINOLOGY, 1975, 67 (02) :309-310

[8] SIMPLE AND SENSITIVE SATURATION ASSAY METHOD FOR MEASUREMENT OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE [J].

BROWN, BL ;

ALBANO, JDM ;

EKINS, RP ;

SGHERZI, AM ;

TAMPION, W .

BIOCHEMICAL JOURNAL, 1971, 121 (03) :561-+

[9] SOME FACTORS AFFECTING DETECTION OF LONG-ACTING THYROID-STIMULATOR PROTECTOR USING MCKENZIE BIOASSAY [J].

DIRMIKIS, S .

JOURNAL OF ENDOCRINOLOGY, 1974, 63 (03) :427-438

[10]

DIRMIKIS S, 1976, THYROID RES, P403

← 1 2 3 →