TRANSIENT IMPAIRMENT OF PERIPHERAL-BLOOD LYMPHOCYTE FUNCTION DURING PUVA THERAPY

被引：33

作者：

MORISON, WL

PARRISH, JA

BLOCH, KJ

KRUGLER, JI

机构：

[1] MASSACHUSETTS GEN HOSP, MED SERV, CLIN IMMUNOL UNIT, BOSTON, MA 02114 USA

[2] MASSACHUSETTS GEN HOSP, MED SERV, ALLERGY UNIT, BOSTON, MA 02114 USA

[3] HARVARD UNIV, SCH MED, DEPT DERMATOL, BOSTON, MA 02115 USA

[4] GTE LABS INC, WALTHAM, MA 02154 USA

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1979年 / 101卷 / 04期

关键词：

D O I：

10.1111/j.1365-2133.1979.tb00016.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Three parameters of immune function—enumeration of circulating T and B lymphocytes and response of lymphocytes to graduated doses of phytohaemagglutinin (PHA)—were examined serially in eleven patients with psoriasis before, during, and after an intensive course of PUVA therapy. A trend was detected for the lymphocyte response to PHA to fall during the first week of treatment and then rise back towards the pre‐treatment level. No alteration was found in the percentage or absolute numbers of circulating T and B lymphocytes. This study shows that routine PUVA therapy can induce an alteration in immune function but that this alteration is slight and short‐lived. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：391 / 397

页数：7

共 15 条

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