KIDNEY CORTICAL NECROSIS INDUCED BY MITOMYCIN-C - A MORPHOLOGICAL EXPERIMENTAL-STUDY

被引：3

作者：

BLANCO, C ^{[1
]}

SAINZMAZA, ML ^{[1
]}

GARIJO, F ^{[1
]}

VALBERNAL, F ^{[1
]}

BUELTA, L ^{[1
]}

FERNANDEZ, F ^{[1
]}

机构：

[1] UNIV CANTABRIA,NATL HOSP MARQUES VALDECILLA,FAC MED,DEPT PATHOL,SANTANDER,SPAIN

来源：

RENAL FAILURE | 1992年 / 14卷 / 01期

关键词：

EXPERIMENTAL STUDY; KIDNEY CORTICAL NECROSIS; MITOMYCIN-C; NEPHROTOXICITY;

D O I：

10.3109/08860229209039114

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Experimental studies on mitomycin-C nephrotoxicity are scanty and mention the occurrence of cortical hemorrhage, tubular necrosis, or hydronephrosis secondary to papillomatous hyperplasia of the uroepithelium. To our knowledge, only one experimental study has mentioned morphological lesions similar to the hemolytic uremic syndrome in the human. In the present study 40 female Wistar rats were studied following unilateral renal perfusion of the left kidney with 2 mg/kg of mitomycin-C. Renal lesions corresponded to cortical necrosis with the presence of large bizarre nuclei. The presence of these nuclear atypias supports a direct toxic effect (alkylation) of the mitomycin or its metabolites on cells.

引用

页码：31 / 39

页数：9

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