A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLIN-4-OLS BY A NOVEL INTRAMOLECULAR BARBIER REACTION AND BY AN INSERTION REACTION - REACTION SCOPE AND LIMITATIONS

被引：23

作者：

KIHARA, M

KASHIMOTO, M

KOBAYASHI, Y

机构：

[1] Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, 770, Sho-machi

来源：

TETRAHEDRON | 1992年 / 48卷 / 01期

关键词：

TETRAHYDROISOQUINOLIN-4-OL; INTRAMOLECULAR BARBIER REACTION; BUTYLLITHIUM; ZEROVALENT NICKEL; SCOPE AND LIMITATION;

D O I：

10.1016/S0040-4020(01)80579-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared from N-(2-iodobenzyl)phenacylamines by an intramolecular Barbier reaction with butyllithium and by an insertion reaction with zerovalent nickel. The scope and limitations of these reactions were discussed.

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页码：67 / 78

页数：12

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