FULMINANT HEPATIC-FAILURE IN NON-HODGKIN LYMPHOMA PATIENTS TREATED WITH CHEMOTHERAPY

被引：47

作者：

SOH, LT

ANG, PT

SNG, I

CHUA, EJ

ONG, YW

机构：

[1] SINGAPORE GEN HOSP, DEPT PATHOL, SINGAPORE, SINGAPORE

[2] SINGAPORE GEN HOSP, DEPT THERAPEUT RADIOL, SINGAPORE, SINGAPORE

[3] SINGAPORE GEN HOSP, DEPT HAEMATOL, SINGAPORE, SINGAPORE

来源：

EUROPEAN JOURNAL OF CANCER | 1992年 / 28A卷 / 8-9期

关键词：

D O I：

10.1016/0959-8049(92)90513-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy is the mainstay of therapy for patients with non-Hodgkin lymphoma. Among side-effects associated with the use of chemotherapy, immunosuppression is one which can be potentially fatal. In hepatitis B carriers, immunosuppression permits widespread infection of the hepatocytes and its subsequent withdrawal causes an "immunological rebound" leading to massive necrosis of hepatocytes. 4 patients who died of fulminant hepatitis following chemotherapy are reported. These were patients with positive hepatitis B serology. Caution is advised when treating non-Hodgkin lymphoma in patients from hepatitis B endemic regions.

引用

页码：1338 / 1339

页数：2

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