THE TYPE-I GROWTH-FACTOR RECEPTORS IN HUMAN BREAST-CANCER

被引：118

作者：

RAJKUMAR, T ^{[1
]}

GULLICK, WJ ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,IMPERIAL CANC RES FUND,ONCOL UNIT,LONDON W12 0HS,ENGLAND

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1994年 / 29卷 / 01期

关键词：

GROWTH FACTORS; RECEPTORS; TYROSINE KINASE; BREAST CANCER; PROGNOSIS;

D O I：

10.1007/BF00666177

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The type 1 family of growth factor receptors includes the EGFR, c-erbB2, c-erbB3, and c-erbB4. All four members of the family are expressed in breast cancer. The EGFR gene and more frequently the c-erbB2 gene are amplified in a proportion of cases. In addition to increased expression as a result of gene amplification, overexpression of perhaps all of the receptors also appears to occur, probably as a result of increased mRNA transcription. Overexpression may have prognostic value and may predict response to current therapies. Finally these GFR proteins represent targets for new types of chemotherapeutic agents.

引用

页码：3 / 9

页数：7

共 40 条

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