EFFECTS OF FATTY-ACIDS ON INVASION THROUGH RECONSTITUTED BASEMENT-MEMBRANE (MATRIGEL) BY A HUMAN BREAST-CANCER CELL-LINE

被引：58

作者：

CONNOLLY, JM ^{[1
]}

ROSE, DP ^{[1
]}

机构：

[1] AMER HLTH FDN, DIV NUTR & ENDOCRINOL, 1 DANA RD, VALHALLA, NY 10595 USA

来源：

CANCER LETTERS | 1993年 / 75卷 / 02期

关键词：

BREAST CANCER; FATTY ACIDS; INVASION;

D O I：

10.1016/0304-3835(93)90198-I

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An in vitro invasion assay system was used to examine the effects of linoleic acid, an omega-6 fatty acid, and two omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, on the invasive capacity of MDA-MB-435 human breast cancer cells. Linoleic acid stimulated, and the omega-3 fatty acids inhibited, tumor cell invasion at concentrations of 0.25 and 0.5 mug/ml. Indomethacin, 20 mug/ml, completely suppressed the stimulatory activity of linoleic acid, suggesting that these fatty acid effects are mediated via eicosanoid biosynthesis.

引用

页码：137 / 142

页数：6

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