BIOMEDICAL APPLICATION OF AN ISOTOPE SELECTIVE NONDISPERSIVE INFRARED SPECTROMETER FOR (CO2)-C-13 AND (CO2)-C-12 CONCENTRATION MEASUREMENTS IN BREATH SAMPLES

被引：15

作者：

HAISCH, M

HERING, P

SCHADEWALDT, P

BROSICKE, H

BRADEN, B

KOLETZKO, S

STEFFEN, C

机构：

[1] UNIV DUSSELDORF,INST LASERMED,D-40001 DUSSELDORF,GERMANY

[2] MAX PLANCK INST QUANTUM OPT,GARCHING,GERMANY

[3] DIABET FORSCHUNGSINST,DUSSELDORF,GERMANY

[4] FREE UNIV BERLIN,KINDERKLIN,BERLIN,GERMANY

[5] UNIV FRANKFURT KLINIKUM,GASTROENTEROL ABT,FRANKFURT,GERMANY

[6] UNIV MUNICH,KINDERPOLIKLIN,MUNICH,GERMANY

[7] BUNDESGESUNDHEITSAMT,INST ARZNEIMITTEL,BERLIN,GERMANY

来源：

ISOTOPENPRAXIS | 1994年 / 30卷 / 2-3期

关键词：

BREATH TEST; CARBON; 13; (CO2)-C-13; HELICOBACTER PYLORI; C-13]LEUCINE; C-13]UREA; C-13]METHACETIN; ISOTOPE SELECTIVE NONDISPERSIVE INFRARED SPECTROSCOPY;

D O I：

10.1080/00211919408046741

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A newly developed isotope selective nondispersive infrared (NDIR) spectrometer for the measurement of (CO2)-C-13 and (CO2)-C-12 concentrations in breath samples was applied as a low cost and very simple to operate alternative to isotope ratio mass spectrometry (IRMS). We used this device for several biomedical applications ([C-13]urea breath test, [C-13]leucine metabolism, [C-13]methacetin catabolism of rats) and found that the results agree very well with IRMS.

引用

页码：253 / 257

页数：5

共 7 条

[1] A SENSITIVE ISOTOPE SELECTIVE NONDISPERSIVE INFRARED SPECTROMETER FOR (CO2)-C-13 AND (CO2)-C-12 CONCENTRATION MEASUREMENTS IN BREATH SAMPLES [J].

HAISCH, M ;

HERING, P ;

FUSS, W ;

FABINSKI, W .

ISOTOPENPRAXIS, 1994, 30 (2-3) :247-251

[2] MEASUREMENT OF (CO2)-C-13/(CO2)-C-12 ABUNDANCE BY NONDISPERSIVE INFRARED HETERODYNE RATIOMETRY AS AN ALTERNATIVE TO GAS ISOTOPE RATIO MASS-SPECTROMETRY [J].

IRVING, CS ;

KLEIN, PD ;

NAVRATIL, PR ;

BOUTTON, TW .

ANALYTICAL CHEMISTRY, 1986, 58 (11) :2172-2178

[3]

KOLETZKO S, IN PRESS

[4]

MILATZ JMW, 1951, J CHEM PHYS, V19, P887, DOI 10.1063/1.1748402

[5] LEUCINE OXIDATION IN-VIVO - INTERINDIVIDUAL AND INTRAINDIVIDUAL VARIATION IN HEALTHY-SUBJECTS AS ASSESSED BY ORAL L-[1-C-13]LEUCINE LOADS [J].

SCHADEWALDT, P ;

BROSICKE, H ;

HAISCH, M ;

MATTHIESEN, U ;

WENDEL, U .

ISOTOPENPRAXIS, 1994, 30 (2-3) :141-150

[6]

STEFFEN C, IN PRESS

[7]

WETZEL K, 1978, Patent No. 137323

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