THE USE OF 2,3-DICHLORO-5,6-DICYANO-PARA-BENZOQUINONE FOR THE SPECTROPHOTOMETRIC DETERMINATION OF SOME CARDIOVASCULAR DRUGS

被引：24

作者：

ISSA, AS

MAHROUS, MS

SALAM, MA

SOLIMAN, N

机构：

[1] Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

来源：

TALANTA | 1987年 / 34卷 / 07期

关键词：

Drug dosage;

D O I：

10.1016/0039-9140(87)80087-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Some basic cardiovascular drugs containing secondary or tertiary amino groups are determined spectrophotometrically. The method is simple and sensitive; it is based on the interaction of the drugs, as n-electron donors, with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as a π-acceptor. The highly coloured radical anion exhibits maximum absorption at 460 nm. The drugs determined are pindolol, dipyridamole, hydralazine hydrochloride, quinidine sulphate, prenylamine lactate and tolazoline hydrochloride. Beer's law is obeyed for these drugs. The procedure is sensitive enough to permit unit dose assay of the individual drugs in their pharmaceutical formulations. The assay results are in accord with the pharmacopoeial assay results. © 1987 Pergamon Journals Ltd.

引用

页码：670 / 672

页数：3

共 26 条

[1] UTILITY OF 2,3-DICHLORO-5,6-DICYANO-P-BENZOQUINONE IN ASSAY OF CODEINE, EMETINE AND PILOCARPINE [J].