ACTION OF DOPAMINE ON HUMAN IRIS

被引：45

作者：

SPIERS, ASD

CALNE, DB

机构：

[1] Medical and Neurological Units, University College Hospital Medical School

来源：

BRITISH MEDICAL JOURNAL | 1969年 / 4卷 / 5679期

关键词：

D O I：

10.1136/bmj.4.5679.333

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dopamine eye drops produce marked dilatation of the pupil in man. This mydriatic effect is inhibited by pretreatment with guanethidine. It is therefore concluded that dopamine acts indirectly via adrenergic nerve endings, rather than exerting a direct effect on adrenergic receptors in the dilator pupillae muscle. In this respect dopamine resembles the phenylalkylamines, such as tyramine, rather than the catecholamines, adrenaline and noradrenaline. If dopamine acts by releasing noradrenaline from adrenergic nerve endings, high concentrations of dopamine could lead to depletion of noradrenaline stores, since synthesis might be unable to keep pace with release. This could be the explanation for the orthostatic hypotension found in patients taking L-dopa for Parkinsonism. © 1969, British Medical Journal Publishing Group. All rights reserved.

引用

页码：333 / &

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