LINEAR NONISOTHERMAL STABILITY STUDIES

A method for evaluation and utilization of data from linear nonisothermal kinetics has been developed. The studies have yielded energy of activation, reaction rate, and stability predictions from a single experiment. The relatively short length of time needed to complete a study and the comparatively few analytical experiments required present a significant advantage over classical kinetic methods. Large volumes of temperature‐controlled space and the need for preliminary screening studies have been eliminated in the method. The advantage of this approach over other nonisothermal kinetic methods lies in the simplicity of equipment required and the ease of analysis of concentration‐time (temperature) curves. The hydrolysis of N‐acetyl‐p‐aminophenol and procainamide hydrochloride has been followed to demonstrate the validity of the theory and the advantages of the method. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company