SPIN LABEL STUDY OF THE EFFECTS OF STEROLS ON EGG LECITHIN BILAYERS

被引：37

作者：

SEMER, R

GELERINTER, E

机构：

[1] KENT STATE UNIV,DEPT PHYS,KENT,OH 44242

[2] KENT STATE UNIV,INST LIQUID CRYSTAL,KENT,OH 44242

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1979年 / 23卷 / 03期

关键词：

D O I：

10.1016/0009-3084(79)90102-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Paramagnetic resonance of cholestane and three fatty acid probes is used to measure the effects of the addition of cholesterol, 7-dehydrocholesterol and ergosterol to egg phosphatidylcholine bilayers. At low concentrations we find that all three sterols effectively align the bilayers. However, concentrations of ergosterol above 15 mol% disorder and disrupt the bilayers. The observed behavior is explained in terms of a steric model in which the steroid nucleus organizes the bilayer and the bulky egosterol tail disorganizes the bilayer. The three fatty acid spin labels are used to probe the layers at different depths, and the data observed are in agreement with the normal presented. © 1979.

引用

页码：201 / 211

页数：11

共 29 条

[1]

BERMAN A, 1974, LIQUID CRYSTALS ORDE, V2, P23

[2]

BUTLER K W, 1970, Biochimica et Biophysica Acta, V219, P514, DOI 10.1016/0005-2736(70)90236-1

[3] MICROVISCOSITY AND ORDER IN HYDROCARBON REGION OF PHOSPHOLIPID AND PHOSPHOLIPID-CHOLESTEROL DISPERSIONS DETERMINED WITH FLUORESCENT PROBES [J].